Abstract #1381

3T Surface-based quantitative susceptibility mapping and T1 relaxometry in relapsing-remitting and progressive multiple sclerosis patients

Nicholas John Eichner¹, Reza Rahmanzadeh¹, Matthias Weigel¹, Muhamed Barakovic¹, Po-Jui Lu¹, Ludwig Kappos¹, Pascal Sati², Daniel S. Reich², Yi Wang³, Jens Kuhle¹, and Cristina Granziera¹

¹Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ²National Institute of Neurological Disordes and Stroke, Bethesda, MD, United States, ³Cornell University, Ithaca, NY, United States

We assessed the presence and extent of cortical abnormalities in patients with relapsing remitting and progressive multiple sclerosis by using surface-based quantitative susceptibility mapping and T1 relaxometry analysis. Our results showed that QSM and T1 maps acquired at 3T MRI are sensitive to cortical damage in MS patients and reveal more extensive areas of alterations in progressive than in relapsing-remitting MS. Changes in cortical QSM and T1 suggest chronic demyelination and possibly iron accumulation.

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