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Abstract #1381

3T Surface-based quantitative susceptibility mapping and T1 relaxometry in relapsing-remitting and progressive multiple sclerosis patients

Nicholas John Eichner1, Reza Rahmanzadeh1, Matthias Weigel1, Muhamed Barakovic1, Po-Jui Lu1, Ludwig Kappos1, Pascal Sati2, Daniel S. Reich2, Yi Wang3, Jens Kuhle1, and Cristina Granziera1
1Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 2National Institute of Neurological Disordes and Stroke, Bethesda, MD, United States, 3Cornell University, Ithaca, NY, United States

We assessed the presence and extent of cortical abnormalities in patients with relapsing remitting and progressive multiple sclerosis by using surface-based quantitative susceptibility mapping and T1 relaxometry analysis. Our results showed that QSM and T1 maps acquired at 3T MRI are sensitive to cortical damage in MS patients and reveal more extensive areas of alterations in progressive than in relapsing-remitting MS. Changes in cortical QSM and T1 suggest chronic demyelination and possibly iron accumulation.

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