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Abstract #1382

Unraveling atrophy, iron and myelin changes in the deep gray matter of multiple sclerosis patients

Giuseppe Pontillo1, Sirio Cocozza1, Serena Monti2, Maria Petracca3, Roberta Lanzillo3, Vincenzo Brescia Morra3, Arturo Brunetti1, and Giuseppe Palma2
1Department of Advances Biomedical Sciences, University of Naples "Federico II", Naples, Italy, 2Institute of Biostructures and Bioimaging, National Research Council, Napoli, Italy, 3Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Naples, Italy

Alterations of magnetic susceptibility are known to occur in the deep gray matter (DGM) of multiple sclerosis (MS) patients, reflecting a mixture of atrophy, iron and myelin changes. We combined the analysis of quantitative susceptibility mapping (QSM) and R1 relaxometry contrasts in order to obtain iron- and myelin-specific maps, from which we estimated mean iron and myelin concentrations as well as total iron and myelin contents for each DGM structure. We found increased mean iron in the basal ganglia of MS patients compared to healthy controls, probably reflecting atrophy-related concentration, along with actual atrophy-independent iron depletion phenomena in the thalamus.

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