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Abstract #1389

White matter magnetic resonance diffusion measures in Multiple Sclerosis with overactive bladder

Xixi Yang1,2,3,4, Martina D Liechti1,2, Baris Kanber3,5, Carole H Sudre5,6,7, Gloria Castellazzi3,8, Jiaying Zhang9,10,11, Marios C Yiannakas3, Gwen Gonzales2, Ferran Prados Carrasco3,5,12, Ahmed T Toosy3, Claudia A. M. G Wheeler-Kingshott3,13,14, and Jalesh N Panicker1,2
1Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, 2Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 3NMR Research Unit, UCL Queen Square MS Centre, London, United Kingdom, 4Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, China, 5Centre for Medical Image Computing, UCL Department of Medical Physics and Bioengineering, London, United Kingdom, 6School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 7Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom, 8Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, 9Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, King’s College London, London, United Kingdom, 10King’s Health Partners, St Thomas’ Hospital, London, United Kingdom, 11Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom, 12Universitat Oberta de Catalunya, Barcelona, Spain, 13Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 14Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

White matter (WM) abnormalities subtending overactive bladder (OAB) symptoms in multiple sclerosis (MS) is poorly understood. MS patients with and without OAB symptoms were recruited to investigate the association between WM changes and OAB symptoms in MS. Lower FA were found in MS with OAB compared with MS without LUTS (p=0.072). An inverse correlation was found between FA and OAB severity (p=0.021) in MS. OAB symptoms are associated with WM anisotropy changes in MS as demonstrated by diffusion-weighted imging (DWI).

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