Abstract #1389

White matter magnetic resonance diffusion measures in Multiple Sclerosis with overactive bladder

Xixi Yang^1,2,3,4, Martina D Liechti^1,2, Baris Kanber^3,5, Carole H Sudre^5,6,7, Gloria Castellazzi^3,8, Jiaying Zhang^9,10,11, Marios C Yiannakas³, Gwen Gonzales², Ferran Prados Carrasco^3,5,12, Ahmed T Toosy³, Claudia A. M. G Wheeler-Kingshott^3,13,14, and Jalesh N Panicker^1,2

¹Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, ²Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ³NMR Research Unit, UCL Queen Square MS Centre, London, United Kingdom, ⁴Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, China, ⁵Centre for Medical Image Computing, UCL Department of Medical Physics and Bioengineering, London, United Kingdom, ⁶School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ⁷Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁸Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, ⁹Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, King’s College London, London, United Kingdom, ¹⁰King’s Health Partners, St Thomas’ Hospital, London, United Kingdom, ¹¹Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom, ¹²Universitat Oberta de Catalunya, Barcelona, Spain, ¹³Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ¹⁴Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

White matter (WM) abnormalities subtending overactive bladder (OAB) symptoms in multiple sclerosis (MS) is poorly understood. MS patients with and without OAB symptoms were recruited to investigate the association between WM changes and OAB symptoms in MS. Lower FA were found in MS with OAB compared with MS without LUTS (p=0.072). An inverse correlation was found between FA and OAB severity (p=0.021) in MS. OAB symptoms are associated with WM anisotropy changes in MS as demonstrated by diffusion-weighted imging (DWI).

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