Abstract #1390

A comparison of seven white matter diffusion microstructure models to study intralesional damage in Multiple Sclerosis

Muhamed Barakovic^1,2, Reza Rahmanzadeh^1,2, Po-Jui Lu^1,2,3, Pietro Maggi^4,5, Pascal Sati⁶, Daniel Reich⁶, Francesco La Rosa^7,8, Meritxell Bach Cuadra^7,9, Simona Schiavi¹⁰, Alessandro Daducci¹⁰, Jens Kuhle¹, Matthias Weigel^1,2,11, Ludwig Kappos¹, and Cristina Granziera^1,2

¹Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Neurologic Clinic and Policlinic, Basel, Switzerland, ²Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ³Digital Technology and Innovation Siemens Healthineers, Princeton, NJ, United States, ⁴Department of Neurology, Saint-Luc University Hospital,Université Catholique de Louvain, Bruxelles, Belgium, ⁵Department of Neurology, Lausanne University and University Hospital, Lausanne, Switzerland, ⁶Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ⁷Signal Processing Laboratory (LTSS), Ecole polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁸Radiology Department, Center for Biomedical Imaging, Lausanne University and University Hospital, Lausanne, Switzerland, Basel, Switzerland, ⁹Radiology Department, Center for Biomedical Imaging, Lausanne University and University Hospital Lausanne, Lausanne, Switzerland, ¹⁰Department of Computer Science, University of Verona, Verona, Italy, ¹¹Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland

In this study, we implemented seven microstructure models based on diffusion-weighted MRI data and investigated their sensitivity in assessing between-lesion differences in axonal content in multiple sclerosis lesions. The result of the analysis showed that all the models selected report lower intracellular volume fraction in white matter lesions compared to normal-appearing white matter. Few of the methods highlighted high sensitivity; however, they also show a different spectrum of ranges in terms of intracellular volume fraction. Whether one of the methods reflect a reliable assessment will be addressed in further studies using postmortem material.

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