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Abstract #1390

A comparison of seven white matter diffusion microstructure models to study intralesional damage in Multiple Sclerosis

Muhamed Barakovic1,2, Reza Rahmanzadeh1,2, Po-Jui Lu1,2,3, Pietro Maggi4,5, Pascal Sati6, Daniel Reich6, Francesco La Rosa7,8, Meritxell Bach Cuadra7,9, Simona Schiavi10, Alessandro Daducci10, Jens Kuhle1, Matthias Weigel1,2,11, Ludwig Kappos1, and Cristina Granziera1,2
1Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Neurologic Clinic and Policlinic, Basel, Switzerland, 2Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 3Digital Technology and Innovation Siemens Healthineers, Princeton, NJ, United States, 4Department of Neurology, Saint-Luc University Hospital,Université Catholique de Louvain, Bruxelles, Belgium, 5Department of Neurology, Lausanne University and University Hospital, Lausanne, Switzerland, 6Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 7Signal Processing Laboratory (LTSS), Ecole polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 8Radiology Department, Center for Biomedical Imaging, Lausanne University and University Hospital, Lausanne, Switzerland, Basel, Switzerland, 9Radiology Department, Center for Biomedical Imaging, Lausanne University and University Hospital Lausanne, Lausanne, Switzerland, 10Department of Computer Science, University of Verona, Verona, Italy, 11Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland

In this study, we implemented seven microstructure models based on diffusion-weighted MRI data and investigated their sensitivity in assessing between-lesion differences in axonal content in multiple sclerosis lesions. The result of the analysis showed that all the models selected report lower intracellular volume fraction in white matter lesions compared to normal-appearing white matter. Few of the methods highlighted high sensitivity; however, they also show a different spectrum of ranges in terms of intracellular volume fraction. Whether one of the methods reflect a reliable assessment will be addressed in further studies using postmortem material.

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