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Abstract #1393

Diffusion Tensor Imaging on Three Pathways: Effect of Ibudilast in Progressive Multiple Sclerosis

Xuemei Huang1, Ken E. Sakaie1, Jian Lin1, Robert J. Fox1, and Mark J. Lowe1
1Imaging Institute, U-15, Cleveland Clinic, Cleveland, OH, United States

Diffusion Tensor Imaging (DTI) analysis was performed in the multi-site phase II trial of ibudilast in progressive multiple sclerosis. This study extends that analysis to three pathways to examine DTI measures in 31 progressive MS patients on treatment and 31 patients on placebo. Probabilistic tracking maps were generated. Mean pathway diffusion measures: longitudinal diffusivity (LD) and transverse diffusivity (TD) are reported. We report here that diffusion measures don’t significantly change over time in the treatment group but we observe a significant change over time in the placebo group.

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