Abstract #1394

Evaluation of different diffusivity and cognitive measures in subcortical regions in healthy subjects and RRMS patients.

Cristian Montalba^1,2,3, Mariana Zurita^1,4, Tomás Labbé^1,5, Marcelo Andia^1,2, Miguel Guevara⁶, Jean-François Mangin⁷, Juan Pablo Cruz², Ethel Ciampi^8,9, Claudia Cárcamo^5,8, Pamela Guevara⁶, and Sergio Uribe^1,2,3

¹Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, ⁴Institute of Cognitive Neuroscience, University College London, London, UK., London, United Kingdom, ⁵Interdisciplinary Center of Neurosciences, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Faculty of Engineering, Universidad de Concepción, Concepción, Chile, Concepción, Chile, ⁷UNATI, Neurospin, CEA,, Université Paris-Saclay, Gif-sur-Yvette, France, ⁸Neurology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁹Neurology Service, Hospital Dr. Sótero del Río, Santiago, Chile, Santiago, Chile

We evaluated different diffusivity measurements of subcortical regions that can be related with different test scores in FAS, SDMT and PASAT test. For this purpose, we evaluated the FA, MD, RD and AD diffusivity maps of U-fibers with the test scores in healthy subjects and RRMS patients. In our sample, FAS test scores are significant linear related with Postcentral gyrus with RD and MD maps in RRMS patients. PASAT test scores are significant linear related with Precentral gyrus with FA and RD maps in healthy subjects. There is no linear relationship between SDMT test score and diffusivity maps.

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