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Abstract #1394

Evaluation of different diffusivity and cognitive measures in subcortical regions in healthy subjects and RRMS patients.

Cristian Montalba1,2,3, Mariana Zurita1,4, Tomás Labbé1,5, Marcelo Andia1,2, Miguel Guevara6, Jean-François Mangin7, Juan Pablo Cruz2, Ethel Ciampi8,9, Claudia Cárcamo5,8, Pamela Guevara6, and Sergio Uribe1,2,3
1Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, 4Institute of Cognitive Neuroscience, University College London, London, UK., London, United Kingdom, 5Interdisciplinary Center of Neurosciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Faculty of Engineering, Universidad de Concepción, Concepción, Chile, Concepción, Chile, 7UNATI, Neurospin, CEA,, Université Paris-Saclay, Gif-sur-Yvette, France, 8Neurology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 9Neurology Service, Hospital Dr. Sótero del Río, Santiago, Chile, Santiago, Chile

We evaluated different diffusivity measurements of subcortical regions that can be related with different test scores in FAS, SDMT and PASAT test. For this purpose, we evaluated the FA, MD, RD and AD diffusivity maps of U-fibers with the test scores in healthy subjects and RRMS patients. In our sample, FAS test scores are significant linear related with Postcentral gyrus with RD and MD maps in RRMS patients. PASAT test scores are significant linear related with Precentral gyrus with FA and RD maps in healthy subjects. There is no linear relationship between SDMT test score and diffusivity maps.

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