Meeting Banner
Abstract #1396

Diffusion tractography evaluation of specificity of PASAT and SDMT to cognitive pathway in multiple sclerosis

Pallab K Bhattacharyya1,2, Robert Fox3, Jian Lin1, Hong Li4, Ken Sakaie1, and Mark Lowe1
1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Radiology, Cleveland Clinic Lerner College of Medicine, CLEVELAND, OH, United States, 3Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, 4Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States

Paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT) are two most commonly used tests to evaluate cognitive performance in MS. The specificity of the two tests to cognitive network in brain was evaluated with diffusion tensor imaging and correlating transverse diffusivity (TD) along different functionally relevant pathways with PASAT/SDMT scores. While SDMT showed association with TD along all pathways (and whole brain white matter), PASAT was associated with only frontoparietal pathway, establishing its specificity to cognitive network.

This abstract and the presentation materials are available to members only; a login is required.

Join Here