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Abstract #1397

Gray matter relaxation rates show different correlation patterns for cognitive impairment and physical disability in Multiple Sclerosis.

Maria Teresa Cassiano1, Roberta Lanzillo2, Bruno Alfano3, Teresa Costabile2, Marco Comerci3, Anna Prinster3, Marcello Moccia2, Rosario Megna3, Vincenzo Brescia Morra2, Arturo Brunetti1, and Mario Quarantelli3
1Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy, 2Department of Neurosciences, Reproductive Science and Odontostomatology, University "Federico II", Naples, Italy, 3Biostructure and Bioimaging Institute, National Research Council, Naples, Italy

To assess voxelwise in gray matter the correlation between relaxation rates and both physical and cognitive impairment in MS, R1 and R2 relaxation rate maps from 241 Relapsing-Remitting MS patients were assessed voxelwise for correlation with EDSS and the percentage of impaired cognitive test.

Inverse correlation between EDSS and R2 were detected throughout the brain, while inverse correlations with R1 were mostly limited to perirolandic and supramarginal cortices.

Cognitive impairment correlated negatively with R1, and to a lesser extent with R2, in the limbic system and dorsolateral prefrontal cortices.

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