To assess voxelwise in gray matter the correlation between relaxation rates and both physical and cognitive impairment in MS, R1 and R2 relaxation rate maps from 241 Relapsing-Remitting MS patients were assessed voxelwise for correlation with EDSS and the percentage of impaired cognitive test.
Inverse correlation between EDSS and R2 were detected throughout the brain, while inverse correlations with R1 were mostly limited to perirolandic and supramarginal cortices.
Cognitive impairment correlated negatively with R1, and to a lesser extent with R2, in the limbic system and dorsolateral prefrontal cortices.
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