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Abstract #1398

Longitudinal progression of cortical thinning differs across MS phenotypes and is clinically relevant: a multicentre study

Paola Valsasina1, Maria A. Rocca1,2, Milagros Hidalgo de la Cruz1, Claudio Gobbi3, Antonio Gallo4, Chiara Zecca3, Alvino Bisecco4, and Massimo Filippi1,2,5
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Department of Neurology, Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland, 4Department of Advanced Medical and Surgical Sciences, and 3T MRI Center, University of Campania “Luigi Vanvitelli”, Naples, Italy, 5Vita-Salute San Raffaele University, Milan, Italy

In this study, we used cortical thickness analysis to investigate the evolution over time of cortical grey matter atrophy in a multicenter cohort of patients with multiple sclerosis (MS) acquired at 3 European sites. We detected a different susceptibility to cortical damage across the different clinical phenotypes of MS, with the involvement of temporal, parietal and occipital regions in relapsing-remitting MS, and an additional frontal involvement in progressive MS. Different annualized cortical thinning rates were found across MS clinical phenotypes. Cortical thinning in frontal and temporal areas was crucial for identifying patients with more severe disability at follow-up.

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