In this study, we used cortical thickness analysis to investigate the evolution over time of cortical grey matter atrophy in a multicenter cohort of patients with multiple sclerosis (MS) acquired at 3 European sites. We detected a different susceptibility to cortical damage across the different clinical phenotypes of MS, with the involvement of temporal, parietal and occipital regions in relapsing-remitting MS, and an additional frontal involvement in progressive MS. Different annualized cortical thinning rates were found across MS clinical phenotypes. Cortical thinning in frontal and temporal areas was crucial for identifying patients with more severe disability at follow-up.
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