Spinal cord pathology is integral to disease symptoms and progression in multiple sclerosis (MS), but imaging methods developed and optimized for studying the spinal cord in vivo with clinically relevant scan times are lacking. Here, we applied a clinically feasible diffusion tensor imaging (DTI) sequence to examine relationships between imaging measures of microstructural damage in the spinal cord and lower extremity functional deficits in low-disability, relapsing-remitting MS patients. Our results show significant correlations between gray matter radial diffusivity and measures of sensation and motor function.
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