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Abstract #1405

Phase Sensitive Inversion Recovery (PSIR) imaging as surrogate for T1 mapping: applications to the spinal cord of multiple sclerosis patients

Nico Papinutto1, Shuiting Cheng1, Mahir Khan1, Jung-Jiin Hsu1, and Roland G Henry1
1UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States

Acquiring images on a phantom and 54 multiple sclerosis patients, we explored the feasibility of T1 mapping using a fast 2D inversion recovery method based on a TrueFISP sequence. We also explored the relationship between T1 values and the intensity of 2D PSIR images. The fast T1 mapping method was shown to be precise, and PSIR intensities shown to have a strong correlation with T1. PSIR has been extensively used to segment in-vivo gray and white matter tissues in the spinal cord, and this study suggests that it can simultaneously provide microscopic information related to the longitudinal relaxation time T1.

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