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Abstract #1406

The Effect of AREX Correction on APT CEST MRI of Lesions within the Spinal Cord of MS Patients

Richard D Lawless1,2, Kristin O'Grady1,3, Mereze Visagie1, Anna Combes1, Haley Feiler1, Francesca Bagnato4, and Seth A. Smith1,2,3
1Vanderbilt University Institute of Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Spinal cord damage in multiple sclerosis often leads to the formation of inflammatory lesions. APT CEST has been proposed as an MRI biomarker capable of detecting the underlying biochemical changes associated with lesion formation, however, CEST findings are susceptible to confounding influences such as the macromolecular magnetization transfer contribution and changes to longitudinal relaxation. AREX is a proposed method which corrects for these contributors and may improve measurement of the CEST component in vivo. In this study we sought to compare MT- and T1-corrected AREX to an uncorrected CEST quantification method in SC lesions of MS patients.

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