Abstract #1419

Detection of multiple sclerosis lesion with T1 and T2* MR Fingerprinting

Ingo Hermann^1,2, Ralf Schmidt¹, Benedikt Rieger¹, Eloy Martinez-Heras³, Elisabeth Solona³, Sara Llufriu³, Achim Gass⁴, Lothar R. Schad¹, and Frank G. Zöllner¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, ²Magnetic Resonance Systems Lab, Department of Imaging Physics, Delft University of Technology, Delft, Netherlands, ³Center of Neuroimmunology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain, ⁴Department of Neurology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany

We evaluated an MRF-EPI sequence for simultaneous T₁ and T₂* quantification in 44 patients with multiple sclerosis (MS) lesions at two scanners. We found significantly increased T₁ and T₂* times in MS lesions with differences up to 100 %. MS lesions resulted in broad distribution in the T₁, T₂* space compared with dense, separated clusters for white and gray matter.

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