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Abstract #1420

Myelin water imaging of Multiple Sclerosis Lesions 

Caroline Köhler1, Hannes Wahl1, Paul Kuntke1, Tjalf Ziemssen2, Jennifer Linn1, and Hagen H. Kitzler1
1Institut und Poliklinik für Diagnostische und Interventionelle Neuroradiologie, University Hospital Carl Gustav Carus, Dresden, Germany, 2Neurology, University Hospital Carl Gustav Carus, Dresden, Germany

Myelin water imaging allows the assessment of relative myelination by estimating the myelin water fraction (MWF). This work investigated if the degree of MWF loss in multiple sclerosis is associated with T1 hypointense and isointense lesions. Within n = 1668 FLAIR lesions of n = 63 MS patients, 79% had a hypointense correlate, and 21% of the lesions had an isointense appearance on non-enhanced T1-weighted images. Significant differences were found for hypointense (MWFmean = 0.126) and isointense (MWFmean = 0.185) lesions. These results show varying degrees of myelin reduction.

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