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Abstract #1421

Simultaneous T2 and T2* Mapping of Multiple Sclerosis Lesions with a Radially Sampled RARE-EPI Hybrid

Carl Herrmann1, Eckart Grönerwäller1, Antje Els1, Joseph Kuchling2,3,4, Friedemann Paul2,3,4, and Thoralf Niendorf1,2
1Berlin Ultrahigh Field Facility (B.U.F.F.) Max Delbrück Center For Molecular Medicine in the Helmoltz Association, Berlin, Germany, 2Experimental und Clinical Research Center (ECRC), Charité-Campus Berlin-Buch, Berlin, Germany, 3NeuroCure Clinical Research Center, Charité – Universitätsmedizin, Berlin, Germany, 4Department of Neurology, Charité – Universitätsmedizin, Berlin, Germany

MRI examinations commonly involve a series of multiple imaging contrasts and MR-metrics, resulting in long examination times and propensity to motion and slice misregistration. Dual or multi-contrast techniques offer substantial scan time reduction. Recognizing this opportunity this work presents a dual contrast RARE-EPI hybrid, that provides T2 (RARE module) and T2* (EPI module) contrast and facilitates simultaneous T2 and T2* mapping in a single radially (under)sampled scan (2-in-1 RARE-EPI). The applicability of 2-in-1 RARE-EPI is demonstrated in an in vivo feasibility study involving patients suffering from multiple sclerosis and healthy controls and benchmarked versus conventional T2 and T2* weighted/mapping techniques.

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