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Abstract #1422

Monitoring the treatment effect of Tecfidera on MS lesion susceptibility with quantitative susceptibility mapping

Xianfu Luo1,2, Elizabeth Sweeney3, Ulrike W. Kaunzner4, Weiyuan Huang1, David Pitt5, Yi Wang1, Susan Gauthier4, and Thanh D. Nguyen1
1Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, 2Department of Radiology, Northern Jiangsu People's Hospital, Yangzhou, China, 3Department of Healthcare Policy and Research, Weill Medical College of Cornell University, New York, NY, United States, 4Department of Neurology, Weill Medical College of Cornell University, New York, NY, United States, 5Yale University, New Haven, CT, United States

Quantitative susceptibility mapping (QSM) has emerged as a sensitive MRI tool for in vivo monitoring inflammation in MS brain. Low-grade inflammation in chronic active lesions have been shown to contain iron-enriched, activated microglia and macrophages on histopathology and have been linked to greater tissue damage. QSM can provide accurate in vivo quantification of iron-laden inflammatory cells. It might be used to assess treatment response.

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