Abstract #1424

Network alterations at rest in multiple sclerosis patients with tremor

Frederique Boonstra¹, Gustavo Noffs^2,3, Thushara Perera^2,4, Vilija Jokubaitis⁵, Adam Vogel^2,4,6, Andrew Evans^3,4, Helmut Butzkueven⁵, Anneke van der Walt⁵, and Scott Kolbe⁵

¹Neuroscience, Monash University, Melbourne, Australia, ²University of Melbourne, Melbourne, Australia, ³Royal Melbourne Hospital, Melbourne, Australia, ⁴Bionics Institute, Melbourne, Australia, ⁵Monash University, Melbourne, Australia, ⁶University of Tübingen, Tübingen, Germany

Almost half of patients with multiple sclerosis (MS) experience tremor, which significantly worsens disability. Pathophysiology studies of MS tremor have highlighted the importance of the cerebello-thalamo tract. This study aimed to use resting-state fMRI to identify brain networks that are dysfunctional in MS tremor. We found significantly higher connectivity within the motor network in tremor patients compared to controls, and the mean activation within the motor network was negatively correlated to tremor. Resting-state fMRI could provide useful markers for studying the pathophysiology of tremor in MS.

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