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Abstract #1424

Network alterations at rest in multiple sclerosis patients with tremor

Frederique Boonstra1, Gustavo Noffs2,3, Thushara Perera2,4, Vilija Jokubaitis5, Adam Vogel2,4,6, Andrew Evans3,4, Helmut Butzkueven5, Anneke van der Walt5, and Scott Kolbe5
1Neuroscience, Monash University, Melbourne, Australia, 2University of Melbourne, Melbourne, Australia, 3Royal Melbourne Hospital, Melbourne, Australia, 4Bionics Institute, Melbourne, Australia, 5Monash University, Melbourne, Australia, 6University of Tübingen, Tübingen, Germany

Almost half of patients with multiple sclerosis (MS) experience tremor, which significantly worsens disability. Pathophysiology studies of MS tremor have highlighted the importance of the cerebello-thalamo tract. This study aimed to use resting-state fMRI to identify brain networks that are dysfunctional in MS tremor. We found significantly higher connectivity within the motor network in tremor patients compared to controls, and the mean activation within the motor network was negatively correlated to tremor. Resting-state fMRI could provide useful markers for studying the pathophysiology of tremor in MS.

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