In a clinical trial, it may be necessary to incorporate multiple centers to get a sufficiently large sample size. Trials that use imaging may suffer from heterogeneity among centers in terms of scanner platform. In the SPRINT-MS trial, diffusion tensor imaging (DTI) measures indicated a larger treatment effect than brain parenchymal fraction (BPF). However, the effect measured by DTI was not statistically significant. In this study, we examine the hypothesis that heterogeneity in scanner type contributed to variance in DTI measures, reducing the statistical power of the measurement.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords