Iron is
known to play a central role in neuronal viability and pathophysiology. Although
susceptibility weighted imaging (SWI) is highly sensitive to iron, few studies
have investigated the effect of age and sex on iron deposition using SWI. Further,
the potential association between iron deposition and myelination is unclear. It
has been suggested that myelin breakdown releases iron, which further acts to
potentiate myelin loss through oxidative mechanisms. Here, we investigate the
association between local iron deposition and age, sex, and myelination,
measured using an advanced myelin content imaging method, on a cohort of
cognitively unimpaired participants.
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