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Abstract #1430

Association of age, sex, and myelin content with regional iron deposition in the human brain

Nikkita Khattar1, Richard G. Spencer1, and Mustapha Bouhrara1
1NIA, NIH, Baltimore, MD, United States

Iron is known to play a central role in neuronal viability and pathophysiology. Although susceptibility weighted imaging (SWI) is highly sensitive to iron, few studies have investigated the effect of age and sex on iron deposition using SWI. Further, the potential association between iron deposition and myelination is unclear. It has been suggested that myelin breakdown releases iron, which further acts to potentiate myelin loss through oxidative mechanisms. Here, we investigate the association between local iron deposition and age, sex, and myelination, measured using an advanced myelin content imaging method, on a cohort of cognitively unimpaired participants.

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