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Abstract #1431

Age-dependence of g-ratio values for subcortical white matter structures in the human brain

Richard Wonjoong Kim1, Nikkita Khattar1, Wenshu Qian1, Joseph Alisch1, Richard G. Spencer1, and Mustapha Bouhrara1
1NIA, NIH, Baltimore, MD, United States

Emerging evidence indicates that myelination and axonal abnormalities could lead to alterations of brain connectivity, contributing to a myriad of neurological disorders. Measurement of myelin to axonal volume, as defined by the g-ratio, has been shown to represent a sensitive and specific metric of neurodevelopment and neurodegeneration. However, only a single study to date has sought to evaluate age-related differences in g-ratio in the adult human brain. Here, we introduce and compare two novel approaches to g-ratio mapping. Both methods revealed a quadratic relationship between g-ratio and age in a large cohort of cognitively unimpaired participants.

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