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Abstract #1436

Assessing MRI-Based Myelin Measures in Multiple Sclerosis and Healthy Brain White Matter

Ahmed M. Elkady1, Zhe Wu1,2, Dumitru Fetco1, Ilana R. Leppert1, Douglas L. Arnold1, Sridar Narayanan1, and David A. Rudko1,3
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 2Techna Institute, University Health Network, Toronto, ON, Canada, 3Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

We comparatively evaluated non-corrected Magnetization Saturation (MTSat), B1-corrected MTsat, wave-CAIPI direct Visualization of Short myelin Transverse component (wave-CAIPI ViSTa), and multi-atlas probabilistic tissue classification in multiple sclerosis (MS) lesions and white matter tracts of healthy and MS subjects. The relationship between ViSTa myelin water fraction (MWF) and MTSat myelin volume fraction (MVF) was altered in MS normal appearing white matter (NAWM) compared NAWM of controls. This may reflect specific alterations in the macromolecular and myelin water pool fractions observed in demyelinating tissue. ViSTa MWF was more sensitive in detecting pathological differences between the MS and control groups.

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