Adults living with Amyoplasia report lower physical activity but no educational or cognitive impairment. Myelin water fraction (MWF) is a quantitative MRI metric useful for examining white matter myelin content. We expect brain MWF to be similar or higher between Amyoplasia and controls in most of the brain but lower in areas associated with physical ability. In 3 adults with Amyoplasia MWF maps were created using a 32-echo T2 GRASE compared to an open-source healthy control atlas. Small reductions in corticospinal tract myelin were observed, while the remainder of the brain examined was similar to the control atlas.