Abstract #1434

Association of Myelination in Internal Capsule with Iron Deposition in the Basal Ganglia in Macaque monkeys

Wenwen Yu¹, Run Pu², Zhe Wu², Hongjian He², Yuequan Shi³, Zuofu Zhou³, Zheng Wang⁴, and Jianhui Zhong^2,5

¹Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, China, ²Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, ³Department of Radiology, Fujian Provincial Maternity and Children’s Hospital of Fujian Medical University, Fuzhou, China, ⁴Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China, ⁵Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

A tight association between iron and myelin content has been demonstrated in the local brain regions. However, it remains unknown whether such relationship exists between adjacent brain regions. Using 8 young and 8 older macaque monkeys, we integrated MRI-based QSM and MWF imaging to examine the relation between iron deposition in components of BG and the myelin content of BG-connecting IC. Our results reveal that the iron of BG is positively correlated with the myelin of IC at different aging stages, and demonstrate that iron in BG also affects the myelin content of the anatomically distinguished yet connected WM structures.

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