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Abstract #1433

Characterisation of MTsat for assessment of intracortical myelination in the developing marmoset brain

Stephen J Sawiak1, M Arsalan Khan2, Gemma Cockcroft3, Edward T Bullmore4, and Angela C Roberts3
1Translational Neuroimaging Laboratory, PDN, University of Cambridge, Cambridge, United Kingdom, 2University of Cambridge, Cambridge, United Kingdom, 3Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom, 4Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom

Changes in myelination are prominent throughout brain development. Here, we assess MTsat as a measure of intracortical myelination in the developing marmoset brain with 38 subjects from infancy to adulthood. We find that the measure is consistent between brains and that across the cortex as a whole, adults differ in apparent myelination compared with infants and early adolescents particularly within central and deeper cortical layers. Regional analysis with this metric will facilitate differentiation between morphological and microstructural developmental changes that cannot be elucidated with conventional structural imaging.

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