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Abstract #1438

Longitudinal follow-up of MS active lesions with 3D inhomogeneous Magnetization Transfer (ihMT)

Lucas Soustelle1,2, Soraya Gherib1,2, Samira Mchinda1,2, Sylviane Confort-Gouny1,2, Arnaud Le Troter1,2, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, Patrick Viout1,2, Lauriane Pini1,2, Claire Costes1,2, Adil Maarouf1,2,3, Bertrand Audoin1,2,3, Audrey Rico1,2,3, Clémence Boutière1,2,3, Fanelly Pariollaud1,2, Françoise Reuter1,2, Victor Nunes Dourado de Carvalho1,2, Véronique Gimenez1,2, Andreea Hertanu1,2, Gopal Varma4, David C Alsop4, Jean Pelletier1,2,3, Guillaume Duhamel1,2, and Olivier M Girard1,2
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3APHM, Hôpital Universitaire Timone, Service de neurologie, Marseille, France, 4Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Assessment of lesion evolution in Multiple Sclerosis (MS) is critical to monitor the disease progression but remains challenging in clinical practice. Inhomogeneous magnetization transfer (ihMT) is a promising technique that has demonstrated sensitivity to demyelination in preclinical and clinical studies. In this work, a 3D ihMT technique was integrated as part of a multiparametric MRI protocol and applied to active MS lesion follow up over a period of six months. Variations of ihMT ratio were compared to those of conventional magnetization transfer imaging and diffusion tensor imaging often used in clinical research to assess demyelination.

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