Little is
known about the relationship between white matter (WM) perfusion and
microstructure across cognitively normal or impaired subjects. WM maintenance
through oligodendrocyte metabolism is an energy-intensive process, so that
myelin homeostasis is particularly sensitive to hypoxia, ischemia, or hypoperfusion.
In addition to substrate delivery, adequate cerebral blood flow (CBF) is
crucial for removal of metabolic byproducts. We investigated associations
between CBF deficits and myelin loss in multiple brain regions in a cohort of cognitively
unimpaired participants across a wide age range. We show significant correlations
between CBF deficits and myelin loss in critical brain structures.
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