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Abstract #1441

Uncharted Waters: Insights From A 100-Subject Myelin Water Imaging Atlas

Taylor Swift-LaPointe1, Irene M. Vavasour2,3, Lisa Eunyoung Lee4, Shawna Abel4, Bretta Russell-Schulz2, Carina Graf1,3, Anika Wurl1, Hanwen Liu1,3, Cornelia Laule1,2,3,5, David K.B. Li2,4, Anthony Traboulsee4, Roger Tam2,6, Lara A. Boyd7, Alex L. MacKay1,2, Shannon H. Kolind1,2,3,4, and Adam V. Dvorak1,3
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 4Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 5Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 7Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada

Data from 100 healthy volunteers (58F/42M, mean age 41 years, range 20-78 years) scanned at 3.0T were used to create a structural template. Voxel-wise mean myelin water fraction (MWF) and intra/extracellular T2 (IET2) atlases were created, and 19 regions of interest were obtained using the joint label fusion framework. Pearson correlations with both age and sex were calculated for MWF and IET2. Mean MWF and IET2 demonstrated clear ranking between brain structures for different age groups, indicating that relative metric values are generally consistent between ROIs. There were no significant correlations between MWF or IET2 and sex.

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