A high-resolution older adult brain template containing full diffusion tensor (DT) information has not been constructed. Available DT templates of low spatial resolution lack fine details, and most are not representative of the older adult brain. Both factors limit spatial normalization accuracy in studies of aging. This work a) introduced a novel approach for constructing a DT template with high spatial resolution based on principles of super-resolution, and using this technique, b) developed and quantitatively evaluated a DT template of the older adult brain with high spatial resolution using high-quality data from 202 non-demented older adults.
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