Disrupted CBF-related measures in clinical diseases has highlighted the importance of reliable baseline data from normal controls. We characterized CBF-related measures in normal aging by acquiring PCASL images in 11 young and 12 elderly subjects. We found that the elderly exhibited longer ATT in the frontal, parietal, temporal, and subcortical regions, reduced CBF in the prefrontal and parietal regions and increased CBF in the subcortical regions, and increased LFF in the superior frontal and paracentral region, compared to the young. This work sets the stage for a larger scale use of PCASL to investigate CBF-related alterations in neurological diseases.
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