Current markers of early neurodegeneration include β-amyloid plaque accumulation and Tau-mediated neuronal injury; both of which are thought to emerge prior to significant cognitive deficits and measurable brain atrophy. Unfortunately, the role of these biomarkers within the cascade of pathophysiological processes of AD remains poorly understood. Impairment in the glymphatic clearance system has garnered attention and is thought to represent a pathway to decline. Here we demonstrate that quantification of glymphatic clearance measures are feasible in healthy controls. Combining these measures with cognitive performance scores and diagnosis will provide insight into the role of the glymphatics system with decline.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords