Abstract #1452

Age-related changes in brain morphology based on a large-scale MRI database of non-human primates

Mayu Iida^1,2, Junichi Hata^2,3,4, Yawara Haga^1,4, Akiko Uematsu^4,5, Fumiko Seki^2,4, Daisuke Yoshimaru^2,3,4, Kei Hagiya⁴, Hirotaka James Okano^3,4, Hideyuki Okano⁴, and Takako Shirakawa¹

¹Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, ²Live Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, ³Division of Regenerative Medicine, Jikei University School of Medicine, Tokyo, Japan, ⁴Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Saitama, Japan, ⁵Center of Evolutionary Cognitive Sciences, Tokyo University Graduate School, Tokyo, Japan

MRI data of 204 large common marmoset colonies were obtained and analyzed regarding brain volume. Marmosets have a brain structure and nerve paths are similar to those in humans compared to other experimental animals. The volume from puberty to old age in six regions (gray matter, deep gray matter, white matter, brainstem, cerebellum, and CSF) could be evaluated. From the viewpoint of volume and variability when performing brain image analysis, it was suggested that marmosets are experimental animals that can evaluate the effects of individual differences at the same level as humans or with slightly less variation than humans.

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