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Abstract #1452

Age-related changes in brain morphology based on a large-scale MRI database of non-human primates

Mayu Iida1,2, Junichi Hata2,3,4, Yawara Haga1,4, Akiko Uematsu4,5, Fumiko Seki2,4, Daisuke Yoshimaru2,3,4, Kei Hagiya4, Hirotaka James Okano3,4, Hideyuki Okano4, and Takako Shirakawa1
1Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, 2Live Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, 3Division of Regenerative Medicine, Jikei University School of Medicine, Tokyo, Japan, 4Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Saitama, Japan, 5Center of Evolutionary Cognitive Sciences, Tokyo University Graduate School, Tokyo, Japan

MRI data of 204 large common marmoset colonies were obtained and analyzed regarding brain volume. Marmosets have a brain structure and nerve paths are similar to those in humans compared to other experimental animals. The volume from puberty to old age in six regions (gray matter, deep gray matter, white matter, brainstem, cerebellum, and CSF) could be evaluated. From the viewpoint of volume and variability when performing brain image analysis, it was suggested that marmosets are experimental animals that can evaluate the effects of individual differences at the same level as humans or with slightly less variation than humans.

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