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Abstract #1453

Blood-brain barrier integrity and cognitive function in a healthy aging population

SAMUEL BARNES1, SHILPY CHOWDHURY2, JENNIFER GARCIA-CANO3, NICOLE M GATTO4, and GRACE J LEE3
1RADIOLOGY, LOMA LINDA UNIVERSITY HEALTH, Loma Linda, CA, United States, 2LOMA LINDA UNIVERSITY, LOMA LINDA, CA, United States, 3PSYCHOLOGY, LOMA LINDA UNIVERSITY SCHOOL OF BEHAVIORAL HEALTH, LOMA LINDA, CA, United States, 4School of Community and Global Health, Claremont Graduate University, CLAREMONT, CA, United States

Dynamic-contrast enhanced (DCE) MRI can detect changes in the blood brain barrier integrity which can be associated with cognitive changes in aging populations. 40 participants from a large cohort underwent contrast MRI and battery of neuropsychological tests. DCE Ktrans values showed a negative correlation with verbal learning and memory testing (RAVLTIR and RAVLTSD). Blood brain barrier disruption, defined by higher Ktrans values, is associated with worse performance on verbal learning, memory and category fluency tests.

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