Abstract #1453

Blood-brain barrier integrity and cognitive function in a healthy aging population

SAMUEL BARNES¹, SHILPY CHOWDHURY², JENNIFER GARCIA-CANO³, NICOLE M GATTO⁴, and GRACE J LEE³

¹RADIOLOGY, LOMA LINDA UNIVERSITY HEALTH, Loma Linda, CA, United States, ²LOMA LINDA UNIVERSITY, LOMA LINDA, CA, United States, ³PSYCHOLOGY, LOMA LINDA UNIVERSITY SCHOOL OF BEHAVIORAL HEALTH, LOMA LINDA, CA, United States, ⁴School of Community and Global Health, Claremont Graduate University, CLAREMONT, CA, United States

Dynamic-contrast enhanced (DCE) MRI can detect changes in the blood brain barrier integrity which can be associated with cognitive changes in aging populations. 40 participants from a large cohort underwent contrast MRI and battery of neuropsychological tests. DCE K_trans values showed a negative correlation with verbal learning and memory testing (RAVLTIR and RAVLTSD). Blood brain barrier disruption, defined by higher K_trans values, is associated with worse performance on verbal learning, memory and category fluency tests.

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