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Abstract #1454

Association of PC-MRI measured Cerebroarterial Pulsatility with Cognitive Impairment and White Matter Hyperintensity in Aged Subjects

Soroush Heidari Pahlavian1,2, Xinhui Wang 2, Samantha Ma1,2, John Ringman2, Helena Chui2, Danny J.J. Wang1,2, and Lirong Yan1,2
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, University of Southern California, Los Angeles, CA, United States

Elevated cerebroarterial pulsations due to arterial stiffness can impart abnormal forces to downstream capillary/tissue leading to microvascular damage, which are thought to be a contributing factor in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease and small vessel disease. In this study, we assessed the utility of two-dimensional (2D) phase-contrast MRI (PC-MRI) in quantifying cerebroarterial pulsations and evaluated the associations of pulsatile and non-pulsatile hemodynamic measures with cognitive performance and white matter hyperintensity (WMH). Our results indicated significant associations of PC-MRI derived pulsatility metrics with cognitive performance and WMH.

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