Abstract #1455

Mean diffusivity in white matter correlates negatively with episodic memory performance in aging, non-demented adults with Down Syndrome

Austin Bazydlo¹, Sigan Hartley¹, Minjie Wu², Patrick Lao³, Douglas C Dean, III¹, Matthew Zammit¹, Sterling Johnson¹, Dana Tudorascu², Annie Cohen², Karly Cody¹, Charles Laymon², William Klunk², Shahid Zaman⁴, Benjamin Handen², Andrew Alexander¹, and Bradley Christian¹

¹University of Wisconsin-Madison, Madison, WI, United States, ²University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ³Columbia University, New York, NY, United States, ⁴University of Cambridge, Cambridge, United Kingdom

People with Down Syndrome (DS) are at an increased risk of developing Alzheimer’s Disease (AD), due to an overproduction of β-amyloid resulting from triplication of the amyloid precursor protein (APP) gene located on chromosome 21. The effect of white matter degradation on early AD-related cognitive decline in the DS population is not known. In this work, we present results from a study of non-demented adults with DS showing correlations between increased mean diffusivity (MD), derived using diffusion tensor imaging (DTI), within several white matter regions of interest and poorer performance on measures of episodic memory.

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