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Abstract #1455

Mean diffusivity in white matter correlates negatively with episodic memory performance in aging, non-demented adults with Down Syndrome

Austin Bazydlo1, Sigan Hartley1, Minjie Wu2, Patrick Lao3, Douglas C Dean, III1, Matthew Zammit1, Sterling Johnson1, Dana Tudorascu2, Annie Cohen2, Karly Cody1, Charles Laymon2, William Klunk2, Shahid Zaman4, Benjamin Handen2, Andrew Alexander1, and Bradley Christian1
1University of Wisconsin-Madison, Madison, WI, United States, 2University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 3Columbia University, New York, NY, United States, 4University of Cambridge, Cambridge, United Kingdom

People with Down Syndrome (DS) are at an increased risk of developing Alzheimer’s Disease (AD), due to an overproduction of β-amyloid resulting from triplication of the amyloid precursor protein (APP) gene located on chromosome 21. The effect of white matter degradation on early AD-related cognitive decline in the DS population is not known. In this work, we present results from a study of non-demented adults with DS showing correlations between increased mean diffusivity (MD), derived using diffusion tensor imaging (DTI), within several white matter regions of interest and poorer performance on measures of episodic memory.

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