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Abstract #1456

Longitudinal trajectory of fibre-specific degeneration in Alzheimer’s disease and mild cognitive impairment

Remika Mito1,2, Robert Smith1, Thijs Dhollander1, Christopher Rowe3,4, Victor Villemagne3,4, Amy Brodtmann1,3, and Alan Connelly1,2
1Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, 3Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia, 4Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Heidelberg, Australia

Alzheimer’s disease (AD) is characterised by degeneration of specific white matter tracts, however the longitudinal trajectory of tract-specific decline has not yet been well described. In this work, we utilise a longitudinal fixel-based analysis framework to investigate specific fibre tracts that exhibit accelerated decline in AD and mild cognitive impairment (MCI). Whole-brain analysis revealed that select fixels exhibit accelerated rates of decline in AD compared to healthy elderly controls, while MCI patients did not exhibit accelerated decline in any fibre structures. Tract-of-interest analysis revealed group differences in tract trajectories over time.

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