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Abstract #1457

Pathway-specific polygenic scores for Alzheimer’s disease are associated with multi-modal structural brain imaging markers in young adults

Judith Harrison1, Xavier Caseras2, Sonya Foley1, Emily Baker2, David Linden3, Peter Holmans2, Derek Jones1, and Valentina Escott-Price2
1CUBRIC, CUBRIC, Cardiff University, Cardiff, United Kingdom, 2MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom, 3School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands

This study explores the relationship between structural brain measurements and novel pathway-specific polygenic scores for Alzheimer’s Disease (AD). We observed associations between the pathway-polygenic profiles, cortical thinning, and changes in white matter signal particularly in the fornix, which have been shown to be markers of Alzheimer’s degeneration, in our sample of healthy young adults. Surprisingly, despite the contribution of APOE to AD risk, the signal in the white matter was stronger when APOE was excluded from the polygenic scores.

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