This study explores the relationship between structural brain measurements and novel pathway-specific polygenic scores for Alzheimer’s Disease (AD). We observed associations between the pathway-polygenic profiles, cortical thinning, and changes in white matter signal particularly in the fornix, which have been shown to be markers of Alzheimer’s degeneration, in our sample of healthy young adults. Surprisingly, despite the contribution of APOE to AD risk, the signal in the white matter was stronger when APOE was excluded from the polygenic scores.
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