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Abstract #1458

White Matter Integrity and Cortical Structure – Dependence on Apolipoprotein E Homozygous ε4 Allele Status

Harald Kugel1, Jonathan Repple2, Janik Goltermann2, Ronny Redlich2, Katharina Dohm2, Claas Kaehler2,3, Dominik Grotegerd2, Katharina Foerster2, Susanne Meinert2, Verena Enneking2, Tim Hahn2, Andreas Jansen4, Axel Krug4, Igor Nenadic4, Simon Schmitt4, Frederike Stein4, Tina Meller4, Dilara Yueksel4, Elena Fischer4, Marcella Rietschel5, Stephanie Witt5, Andreas J Forstner6,7, Markus Noethen6, Andreas Johnen8, Tilo Kircher4, Bernhard T Baune2, Udo Dannlowski2, and Nils Opel2
1Institute of Clinical Radiology, University of Muenster, Muenster, Germany, 2Department of Psychiatry, University of Muenster, Muenster, Germany, 3Department of Mathematics and Computer Science, University of Muenster, Muenster, Germany, 4Department of Psychiatry, University of Marburg, Marburg, Germany, 5Department of Genetic Epidemiology in Psychiatry, University of Heidelberg, Mannheim, Germany, 6Institute of Human Genetics, University of Bonn, Bonn, Germany, 7Centre for Human Genetics, University of Marburg, Marburg, Germany, 8Department of Neurology, University of Muenster, Muenster, Germany

Apoliprotein E (APOE) genotype status, a predictor of Alzheimer's disease, has been associated with brain structural alterations. Supplementing previous research that primarily focused on hippocampal morphometry, we found a widespread effect of APOE allele status on cortical surface area and white matter microstructure. There is a significant cortical surface area decrease in 57 out of 68 cortical brain regions in APOE ε4 homozygous carriers. Furthermore, APOE ε4 homozygous carriers showed significant and widespread reductions in fractional anisotropy in corpus callosum, right internal and external capsule, left corona radiata and right fornix.

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