Abstract #1458

White Matter Integrity and Cortical Structure – Dependence on Apolipoprotein E Homozygous ε4 Allele Status

Harald Kugel¹, Jonathan Repple², Janik Goltermann², Ronny Redlich², Katharina Dohm², Claas Kaehler^2,3, Dominik Grotegerd², Katharina Foerster², Susanne Meinert², Verena Enneking², Tim Hahn², Andreas Jansen⁴, Axel Krug⁴, Igor Nenadic⁴, Simon Schmitt⁴, Frederike Stein⁴, Tina Meller⁴, Dilara Yueksel⁴, Elena Fischer⁴, Marcella Rietschel⁵, Stephanie Witt⁵, Andreas J Forstner^6,7, Markus Noethen⁶, Andreas Johnen⁸, Tilo Kircher⁴, Bernhard T Baune², Udo Dannlowski², and Nils Opel²

¹Institute of Clinical Radiology, University of Muenster, Muenster, Germany, ²Department of Psychiatry, University of Muenster, Muenster, Germany, ³Department of Mathematics and Computer Science, University of Muenster, Muenster, Germany, ⁴Department of Psychiatry, University of Marburg, Marburg, Germany, ⁵Department of Genetic Epidemiology in Psychiatry, University of Heidelberg, Mannheim, Germany, ⁶Institute of Human Genetics, University of Bonn, Bonn, Germany, ⁷Centre for Human Genetics, University of Marburg, Marburg, Germany, ⁸Department of Neurology, University of Muenster, Muenster, Germany

Apoliprotein E (APOE) genotype status, a predictor of Alzheimer's disease, has been associated with brain structural alterations. Supplementing previous research that primarily focused on hippocampal morphometry, we found a widespread effect of APOE allele status on cortical surface area and white matter microstructure. There is a significant cortical surface area decrease in 57 out of 68 cortical brain regions in APOE ε4 homozygous carriers. Furthermore, APOE ε4 homozygous carriers showed significant and widespread reductions in fractional anisotropy in corpus callosum, right internal and external capsule, left corona radiata and right fornix.

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