The CBF and iron deposition evaluation are commonly used in alzheimer's disease. we analyzed the changes and correlations of CBF and iron deposition in different stages of AD. ASL and QSM identified several abnormal brain regions of interest, which were sensitive to tissue alterations in each stage. This study found QSM was detected in the early stage of AD, which is expected to be an effective tool for early AD diagnosis and timely intervention. Additionally, the iron deposition and CBF in the globus pallidum and putamen flow negatively correlated in the AD group that may be relevant to pathologic changes.