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Abstract #1461

Study of the cerebral blood flow and Iron Deposition metabolism in Alzheimer’s disease using ASL-MRI and QSM-MRI

Dongxue Li1, Yuancheng Liu1, Zhenliang Xiong1, Xianchun Zeng1, Lisha Nie2, Pu-Yeh Wu2, and Rongpin Wang1
1Department of Radiology, Guizhou Provincial People's Hospital, Guiyang, China, 2GE Healthcare, MR Research, Beijing, China

The CBF and iron deposition evaluation are commonly used in alzheimer's disease. we analyzed the changes and correlations of CBF and iron deposition in different stages of AD. ASL and QSM identified several abnormal brain regions of interest, which were sensitive to tissue alterations in each stage. This study found QSM was detected in the early stage of AD, which is expected to be an effective tool for early AD diagnosis and timely intervention. Additionally, the iron deposition and CBF in the globus pallidum and putamen flow negatively correlated in the AD group that may be relevant to pathologic changes.

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