Abstract #1462

Brain oxygen extraction fraction in cognitive impairment: a potential tool to differentiate between Alzheimer’s and vascular dementia

Dengrong Jiang¹, Zixuan Lin¹, Peiying Liu¹, Sandeepa Sur¹, Cuimei Xu¹, George Pottanat¹, Kaisha Hazel¹, Sevil Yasar², Paul Rosenberg³, Marilyn Albert⁴, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁴Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States

Alzheimer’s disease (AD) and vascular dementia (VD) are the two most common types of cognitive impairment. However, there is still a lack of effective tools for their differential diagnosis. In this work, we demonstrated that OEF is differentially (in opposite direction) affected by AD and vascular pathology. Among patients with cognitive impairment, patients with low OEF are associated with more AD pathology and less vascular pathology; and the opposite can be said for patients with high OEF. These findings suggest that OEF may provide valuable information in differentiating AD and VD.

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