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Abstract #1462

Brain oxygen extraction fraction in cognitive impairment: a potential tool to differentiate between Alzheimer’s and vascular dementia

Dengrong Jiang1, Zixuan Lin1, Peiying Liu1, Sandeepa Sur1, Cuimei Xu1, George Pottanat1, Kaisha Hazel1, Sevil Yasar2, Paul Rosenberg3, Marilyn Albert4, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States, 4Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States

Alzheimer’s disease (AD) and vascular dementia (VD) are the two most common types of cognitive impairment. However, there is still a lack of effective tools for their differential diagnosis. In this work, we demonstrated that OEF is differentially (in opposite direction) affected by AD and vascular pathology. Among patients with cognitive impairment, patients with low OEF are associated with more AD pathology and less vascular pathology; and the opposite can be said for patients with high OEF. These findings suggest that OEF may provide valuable information in differentiating AD and VD.

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