Meeting Banner
Abstract #1471

Comparison of locus coeruleus volume by using a high spatial-resolution MRI template among AD, MCI, and healthy controls

Sung-Jong Eun1, Sang-Young Kim2, Young Noh3, and Eung-Yeop Kim4
1Health IT Research Center, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea, Republic of, 2Center for Parkinson's Disease and Dementia, Neuroscience Research Institute, Gachon University, Incheon, Korea, Republic of, 3Department of Neurology, Gil Medical Center, Gachon University of College of Medicine, Incheon, Korea, Republic of, 4Department of Radiology, Gil Medical Center, Gachon University of College of Medicine, Incheon, Korea, Republic of

Locus coeruleus (LC) is involved in regulating working memory, learning, attention, and arousal/wakefulness in the brain and accumulating evidence suggest that the LC is the initial brain region that the earliest pathological changes occur in Alzheimer’s disease (AD). We employed neuromelanin-sensitive MRI to detect the changes of LC volumes in AD. Automatic segmentation of the LC revealed profound reductions in LC volumes in AD dementia as compared to prodromal AD and/or healthy controls. Our finding suggests that volumetric reduction of the LC would be a non-invasive biomarker for detecting early pathological changes in AD.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here