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Abstract #1474

A novel MRI biomarker for the characterization of early and later forms of Alzheimer’s disease

Marianna Inglese1, Haonan Lu2,3, Matthew Grech-Sollars1,4, and Eric O Aboagye1
1Surgery and Cancer, Imperial College, London, United Kingdom, 2Cancer Imaging Centre, Imperial College, London, United Kingdom, 3Ovarian Cancer Action Research Centre, Imperial College, London, United Kingdom, 4Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom

Alzheimer’s disease(AD) is the most common form of dementia. In the past few decades, great advances have been made in the understanding of its pathophysiology due to the use of biomarkers. Imaging biomarkers, either based on structural brain changes and metabolic alterations alone, or in conjunction with cerebrospinal fluid(CSF) biomarkers, can be informative of the ongoing pathological processes occurring in a patient with AD. In our method, we propose a novel MRI biomarker that is based on the extraction of structural features from a T1-w MRI scan, and it provides biological characterization of early and later forms of AD.

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