For the first time, we applied fixel-based analysis (FBA) to investigate fibre tract-specific WM changes in early-onset Alzheimer’s disease (EOAD) and late-onset AD (LOAD). To test the repeatability of the results, we repeated the analysis in two independent cohort. We demonstrated that EOAD in two cohorts had more widespread WM tracts loss than LOAD. The different FD extended from the limbic system to long posterior projection regions. Further, we found that FD, rather than FC, had a higher sensitivity in detecting WM loss of EOAD, and vice versa in LOAD. Results may provide clinical clues for early diagnosis of EOAD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords