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Abstract #1477

 The Evaluation of Cerebral Blood Flow Deficits in Parkinson’s Disease Dementia using ASL-MRI at 3T 

Sena Tunçer1, Dilek Betul Arslan1, Tanya Ipek Deniz2, Oznur Aslan 3, Ani Kiçik4,5, Kardelen Eryürek4,6, Emel Erdoğdu4,7, Zerrin Yildirim8, Zeynep Tüfekcioglu8, Basar Bilgic8, Hasmet Hanagasi8, Hakan Gürvit8, Tamer Demiralp4,9, and Esin Ozturk-Isık1
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Department of Electrical and Electronic Engineering, Bogazici University, Istanbul, Turkey, 3Department of Biomedical Engineering, Namik Kemal University, Tekirdağ, Turkey, 4Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 5Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, 6Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, 7Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, 8Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 9Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

This study aims to find cerebral blood flow (CBF) deficits in Parkinson’s disease dementia (PDD). ASL-MRI was utilized to obtain CBF values in PD patients with different stages of cognitive decline at 3T. The CBF values were compared using a whole brain voxel-based analysis. The findings of this study revealed that the PDD group had significant CBF reductions in posterior cerebral areas, mostly in visual cortices, but also in medial parietal areas, and cortical and thalamic components of dorsolateral prefrontal fronto-striatal circuit as compared to both PD group with mild cognitive impairment (PD-MCI) and the cognitively normal PD group (PD-CN).

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