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Abstract #1479

CDR stage of MCI in Parkinson’s disease is associated with whiter matter hyperintensities characteristics: an initial comparison study

Hanyu Wei1, Le He1, Rongsong Zhou2, Xuesong Li3, Shuo Chen1, Yu Ma2, and Rui Li1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China, 3School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China

The aim of this study was to investigate the white matter hyperintensities (WMH) on FLAIR MRI in patients of Parkinson’s disease (PD) with questionable mild cognitive impairment (PD-Q) and without MCI (PD-N). Automatic segmentation and artificial localization of WMH were done to accurately describe WMH characteristics. By the Clinical Dementia Rating (CDR) staging dementia in PD patients, the WMH showed more in the region of bilateral cornu occipital in PD-Q than PD-N. This finding may initially improve understanding about the association between WMH and PD cognitive dysfunction.

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