Abstract #1479

CDR stage of MCI in Parkinson’s disease is associated with whiter matter hyperintensities characteristics: an initial comparison study

Hanyu Wei¹, Le He¹, Rongsong Zhou², Xuesong Li³, Shuo Chen¹, Yu Ma², and Rui Li¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China, ³School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China

The aim of this study was to investigate the white matter hyperintensities (WMH) on FLAIR MRI in patients of Parkinson’s disease (PD) with questionable mild cognitive impairment (PD-Q) and without MCI (PD-N). Automatic segmentation and artificial localization of WMH were done to accurately describe WMH characteristics. By the Clinical Dementia Rating (CDR) staging dementia in PD patients, the WMH showed more in the region of bilateral cornu occipital in PD-Q than PD-N. This finding may initially improve understanding about the association between WMH and PD cognitive dysfunction.

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