Abstract #1483

Quantitative measurement of age-related change of myelin content in a large sample of Chinese population

Junye Yao¹, Qiqi Tong¹, Ting Gong¹, Qiuping Ding¹, Yi Sun², Peipeng Liang³, Kuncheng Li⁴, Hongjian He¹, and Jianhui Zhong^1,5

¹Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, ²MR Collaboration, Siemens Healthcare Ltd, Shanghai, China, ³School of Psychology, Capital Normal University, Beijing, China, ⁴Department of radiology, Xuanwu Hospital Capital Medical University, Beijing, China, ⁵Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Magnetic resonance structural images of 902 Chinese subjects were used to study the change of myelin content with the age based on the T1-weighted/T2-weighted ratio. Significant quadratic age effects were observed in white matter tracts and subcortical areas. The gender difference was reflected in the results that the myelin content levels are higher and begin to decline earlier in women. The inverted U-shape myelin-vs-age curve accords with the existing research literature. However, the age of the observed peaks may have been delayed by iron deposition in basal ganglia.

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