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Abstract #1483

Quantitative measurement of age-related change of myelin content in a large sample of Chinese population

Junye Yao1, Qiqi Tong1, Ting Gong1, Qiuping Ding1, Yi Sun2, Peipeng Liang3, Kuncheng Li4, Hongjian He1, and Jianhui Zhong1,5
1Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens Healthcare Ltd, Shanghai, China, 3School of Psychology, Capital Normal University, Beijing, China, 4Department of radiology, Xuanwu Hospital Capital Medical University, Beijing, China, 5Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Magnetic resonance structural images of 902 Chinese subjects were used to study the change of myelin content with the age based on the T1-weighted/T2-weighted ratio. Significant quadratic age effects were observed in white matter tracts and subcortical areas. The gender difference was reflected in the results that the myelin content levels are higher and begin to decline earlier in women. The inverted U-shape myelin-vs-age curve accords with the existing research literature. However, the age of the observed peaks may have been delayed by iron deposition in basal ganglia.

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