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Abstract #1486

Progressive Increased Degree Centrality in Alzheimer’s Disease and Mild Cognitive Impairment: A Resting-state fMRI Study

Yuan Luo1, Chunchao Ma2, Xianchang Zhang3, Xiuwei Fu4, and Hongyan Ni5
1Department of Radiology, First Central Clinical College, Tianjin Medical University, Tianjin, China, 2Department of Neurology, Tianjin First Central Hospital, Tianjin, China, 3MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 4Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China, 5Department of Radiology, Tianjin First Central Hospital, Tianjin, China

Brain network alterations remain poorly understood in mild cognitive impairment (MCI). This functional magnetic resonance imaging (fMRI) study aimed to investigate the degree centrality alterations in patients with Alzheimer's disease (AD) and MCI using graph theory analyses based on a population-specific template, as well as associations with neuropsychological test scores. The degree centrality of the left middle frontal gyrus and left medial superior frontal gyrus increased as patients’ cognitive function and daily activities declined. These findings suggest that abnormalities in the network topology progress in the prodromal and clinical stages of AD and are associated with clinical manifestations.

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