Brain network alterations remain poorly understood in mild cognitive impairment (MCI). This functional magnetic resonance imaging (fMRI) study aimed to investigate the degree centrality alterations in patients with Alzheimer's disease (AD) and MCI using graph theory analyses based on a population-specific template, as well as associations with neuropsychological test scores. The degree centrality of the left middle frontal gyrus and left medial superior frontal gyrus increased as patients’ cognitive function and daily activities declined. These findings suggest that abnormalities in the network topology progress in the prodromal and clinical stages of AD and are associated with clinical manifestations.
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