Abstract #1487

Role of Diffusion MRI-Derived Free Water Fraction in Predicting Progression to Alzheimer’s Disease Dementia from Mild Cognitive Impairment

Virendra R Mishra¹, Karthik R Sreenivasan¹, Xiaowei Zhuang¹, Zhengshi Yang¹, Dietmar Cordes^1,2, Jeffrey Cummings^1,3, Jessica Caldwell¹, and Aaron Ritter¹

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²University of Colorado, Boulder, Boulder, CO, United States, ³Department of Brain Health, University of Nevada, Las Vegas, Las Vegas, NV, United States

We hypothesized that diffusion-MRI (dMRI)-derived free-water fraction (f_iso) will show a significantly lower and a faster change over time in mild cognitive impaired (MCI) participants who progressed to Alzheimer’s disease (AD) dementia in various cortical, subcortical, and white-matter fiber tracts compared to those who did not progress to AD dementia. Utilizing five β-Amyloid (Aβ) positive (+)/ApoE-4 carriers MCI participants who progressed to AD dementia within one-year, and thirteen Aβ+/ApoE-4 carriers MCI participants who did not progress to AD dementia within one-year, we showed that although the relationship between various cortical/subcortical volume and f_iso is complex, it was distinct between groups.

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