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Abstract #1487

Role of Diffusion MRI-Derived Free Water Fraction in Predicting Progression to Alzheimer’s Disease Dementia from Mild Cognitive Impairment

Virendra R Mishra1, Karthik R Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Dietmar Cordes1,2, Jeffrey Cummings1,3, Jessica Caldwell1, and Aaron Ritter1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado, Boulder, Boulder, CO, United States, 3Department of Brain Health, University of Nevada, Las Vegas, Las Vegas, NV, United States

We hypothesized that diffusion-MRI (dMRI)-derived free-water fraction (fiso) will show a significantly lower and a faster change over time in mild cognitive impaired (MCI) participants who progressed to Alzheimer’s disease (AD) dementia in various cortical, subcortical, and white-matter fiber tracts compared to those who did not progress to AD dementia. Utilizing five β-Amyloid (Aβ) positive (+)/ApoE-4 carriers MCI participants who progressed to AD dementia within one-year, and thirteen Aβ+/ApoE-4 carriers MCI participants who did not progress to AD dementia within one-year, we showed that although the relationship between various cortical/subcortical volume and fiso is complex, it was distinct between groups.

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