Abstract #1488

Imaging cerebral ketone metabolism with hyperpolarized 13C magnetic resonance spectroscopy

Lydia M Le Page^1,2, Soo Hyun Shin³, Kai Qiao^1,2, and Myriam M Chaumeil^1,2

¹Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, United States, ²Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Bioengineering, University of California, Berkeley, Berkeley, CA, United States

As ketogenic diets have been shown to elicit cognitive improvements in Alzheimer’s disease (AD) patients, non-invasive methods allowing for in vivo monitoring of brain ketone metabolism are critically needed to understand and monitor these observations. We hypothesized that ¹³C magnetic resonance spectroscopy of hyperpolarized (HP) [1-¹³C] beta-hydroxybutyrate (BHB) could be used to monitor response to ketogenic diets in health and AD. Here, we characterized HP [1-¹³C] BHB and validated an AD mouse model for application of our HP probe. We also carried out the first proof-of-concept acquisition of data showing in vivo metabolism of HP BHB in the mouse brain.

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