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Abstract #1488

Imaging cerebral ketone metabolism with hyperpolarized 13C magnetic resonance spectroscopy

Lydia M Le Page1,2, Soo Hyun Shin3, Kai Qiao1,2, and Myriam M Chaumeil1,2
1Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, United States, 2Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Bioengineering, University of California, Berkeley, Berkeley, CA, United States

As ketogenic diets have been shown to elicit cognitive improvements in Alzheimer’s disease (AD) patients, non-invasive methods allowing for in vivo monitoring of brain ketone metabolism are critically needed to understand and monitor these observations. We hypothesized that 13C magnetic resonance spectroscopy of hyperpolarized (HP) [1-13C] beta-hydroxybutyrate (BHB) could be used to monitor response to ketogenic diets in health and AD. Here, we characterized HP [1-13C] BHB and validated an AD mouse model for application of our HP probe. We also carried out the first proof-of-concept acquisition of data showing in vivo metabolism of HP BHB in the mouse brain.

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