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Abstract #1489

Sensitivity of ASL MRI for Detecting Perfusion Abnormalities in Frontotemporal Dementia: Preliminary Comparison with 15O-water PET

Tracy Ssali1,2, Lucas Narciso1,2, Justin Hicks1,2, Matthias G√ľnther3, Frank Prato1,2, Udunna Anazodo1,2, Elizabeth Finger4, and Keith St Lawrence1,2
1Lawson Health Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, 4Department of Clinical Neurological Sciences, Western University, London, ON, Canada

The ability of arterial spin labeling (ASL) to detect perfusion abnormalities in clinical populations, such as frontotemporal dementia, can be limited by poor signal to noise and transit-time artefacts. Recent advances in ASL imaging protocols should enable detection of more subtle perfusion abnormalities. This study presents a head-to-head comparison of regional hypoperfusion detected by ASL and PET with radiolabeled water (15O-water) - the gold standard for measuring CBF in humans. While 15O-water PET data showed greater sensitivity, as identified by larger and focal clusters on the t-maps, similar areas of hypoperfusion were identified by ASL, particularly with relative CBF.

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