Abstract #1489

Sensitivity of ASL MRI for Detecting Perfusion Abnormalities in Frontotemporal Dementia: Preliminary Comparison with 15O-water PET

Tracy Ssali^1,2, Lucas Narciso^1,2, Justin Hicks^1,2, Matthias Günther³, Frank Prato^1,2, Udunna Anazodo^1,2, Elizabeth Finger⁴, and Keith St Lawrence^1,2

¹Lawson Health Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, ⁴Department of Clinical Neurological Sciences, Western University, London, ON, Canada

The ability of arterial spin labeling (ASL) to detect perfusion abnormalities in clinical populations, such as frontotemporal dementia, can be limited by poor signal to noise and transit-time artefacts. Recent advances in ASL imaging protocols should enable detection of more subtle perfusion abnormalities. This study presents a head-to-head comparison of regional hypoperfusion detected by ASL and PET with radiolabeled water (¹⁵O-water) - the gold standard for measuring CBF in humans. While ¹⁵O-water PET data showed greater sensitivity, as identified by larger and focal clusters on the t-maps, similar areas of hypoperfusion were identified by ASL, particularly with relative CBF.

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