Abstract #1491

Greater BBB permeability change in APOE4 carrier in cognitively normal and mild cognitive impaired subjects: a new imaging phenotype for APOE4

Won-Jin Moon¹, Ilheon Ha¹, Changmok Lim¹, Yaehoon Kim¹, Yeolsil Moon², and Seol-Heui Han²

¹Radiology, Konkuk University Medical Center, Seoul, Republic of Korea, ²Neurology, Konkuk University Medical Center, Seoul, Republic of Korea

In normal and cogntively impaired subjects, BBB permeability of hippocampus is increased in APOE4 carrier group than in APOE4 non-carrier group. After adjusting for education years, and medial temporal lobar atrophy, the only valuable predicting factor for predicting cognitive function was BBB permeability of hippocampus. Our study indicates that BBB permeability imaging can be a distinct imaging phenotype of APOE4 mutation as well as an early imaging marker for clinical decline in cognitive impaired subjects.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.