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Abstract #1491

Greater BBB permeability change in APOE4 carrier in cognitively normal and mild cognitive impaired subjects: a new imaging phenotype for APOE4

Won-Jin Moon1, Ilheon Ha1, Changmok Lim1, Yaehoon Kim1, Yeolsil Moon2, and Seol-Heui Han2
1Radiology, Konkuk University Medical Center, Seoul, Republic of Korea, 2Neurology, Konkuk University Medical Center, Seoul, Republic of Korea

In normal and cogntively impaired subjects, BBB permeability of hippocampus is increased in APOE4 carrier group than in APOE4 non-carrier group. After adjusting for education years, and medial temporal lobar atrophy, the only valuable predicting factor for predicting cognitive function was BBB permeability of hippocampus. Our study indicates that BBB permeability imaging can be a distinct imaging phenotype of APOE4 mutation as well as an early imaging marker for clinical decline in cognitive impaired subjects.

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